Oricol™
Our simple device for rectal mucosal sampling
Oricol™ is a simple medical device for collecting high-quality samples at the rectal mucosa. It provides unprecedented access to the host-microbiome interface where disease begins.
Simple
The collection procedure can be performed on any adult (subject to safety criteria) without the need for any type of bowel preparation or anaesthesia. It can be conducted by any clinical professional trained in proctoscopy.
Quick
The collection procedure takes just a few minutes. In many cases, health practitioners can discuss the procedure and take the sample all within the same appointment.
Safe & Well Tolerated
The procedure is safe and well tolerated. The majority of patients find that it is far less unpleasant than the alternative, where they are required to take a sample of their stool. The device is CE marked and has been successfully used on over 6,000 patients.
Effective
Oricol™ captures at least 250 times richer in biomarkers than the existing sampling method, stool sampling. In addition, the potential to characterise the host-microbiome interface is highly accurate.
The Procedure
A simple, standardised approach to collecting high-quality samples from the host-microbiome interface
Watch the Procedure
See Oricol™ in action during a clinical demonstration
Positioning
The subject lies on their side, and a standard clinical proctoscope (disposable and included with the kit) is inserted into the rectum (a very common procedure).
Preparation
The device is then prepared and inserted into the proctoscope. A syringe is used to inject 80ml of air into the device.
Inflation
An elasticated membrane (balloon) is inflated against the rectal wall. The membrane is hydrophilic, attracting a thin layer of the rectal biofilm to its surface.
Retraction
After 10 seconds the membrane is retracted (back into the device), and the device removed from the proctoscope, which is then removed and disposed of.
Stabilisation
A stabilisation buffer is added to the sample (contained in a detachable component of the device), which is then sent to the laboratory for analysis.
Disposal
The remainder of the device and syringe is then disposed of according to local legislation.
Why Rectal Mucosa?
Most microbiome studies rely on stool samples — convenient but noisy, inconsistent, and not representative of the disease-relevant environment. Oricol samples where it matters most: the host-microbiome interface where disease begins.
Rectal Mucosa
Direct access to the host-microbiome interface where disease biology happens. Captures both epithelial cells and microbes in their natural environment.
Stool Samples
Composite of digested material and transient microbes. Often noisy and not representative of disease pathways.
Comparative Analysis
Applications
Discover how Oricol™ technology is advancing clinical research and enabling breakthrough discoveries in microbiome science across multiple therapeutic areas.
Fred Hutchinson Cancer Research Center Partnership
HIV Clinical Research
Comprehensive mucosal sampling for HIV research, providing unprecedented insights into host-microbe interactions at the rectal mucosa.
Calprotectin Validation & Advanced Biomarker Discovery
Inflammatory Bowel Disease
Revolutionary approach to IBD diagnosis through advanced mucosal sampling, providing superior diagnostic accuracy compared to traditional stool-based methods.
Comprehensive Host-Microbe Interaction Studies
Mucosal Barrier Function
Unlock the full potential of mucosal microbiome research with comprehensive analysis of barrier function, immune responses, and microbial communities.
Precision Testing for Drug & Supplement Efficacy
Therapeutic Development
Accelerate therapeutic development with precise evaluation of drug and nutritional interventions at the critical mucosal interface.
Integrated Host-Microbe Interaction Analysis
Systems Biology & Multi-Omics
Generate comprehensive multi-omic datasets for systems-level understanding of host-microbe interactions and disease mechanisms.
Next-Generation Clinical Research Platform
Clinical Trial Enablement
Transform clinical trials with non-invasive mucosal sampling that provides superior data quality and patient compliance compared to traditional methods.
Ready to Transform Your Research?
Discover how Oricol™ technology can revolutionise your clinical studies and research programmes
Collaborate With Biomii Health
Partner with us to advance microbiome science using our revolutionary Oricol device technology.
Partnership Opportunities
Research Collaboration
Access cutting-edge Oricol technology for your research studies and clinical trials.
Clinical Partnerships
Integrate our diagnostic capabilities into your clinical practice and patient care.
Technology Licensing
License our proprietary Oricol technology for your commercial applications.
Biobank & Data Access
Access our extensive biobanks and clinical datasets for your research and development projects.
Our Team
Archie Lywood
CEO
Dr. Daniel Wise
Chief Scientific Officer
Prof. Andrew Page
Chief Technology Officer
Hugo Lywood
Chairman